David J Hackam Selected Research

Toll-Like Receptor 4

1/2021	Necrotizing enterocolitis induces T lymphocyte-mediated injury in the developing mammalian brain.
1/2021	The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling.
1/2021	Insights image for "The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling."
1/2020	A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis.
1/2019	Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.
8/2017	TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice.
4/2016	Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis.
12/2015	HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.
6/2015	Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).
5/2015	Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus.

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David J Hackam Research Topics

Disease

29	Necrotizing Enterocolitis 01/2022 - 06/2004
23	Inflammation (Inflammations) 01/2022 - 06/2004
7	Wounds and Injuries (Trauma) 01/2018 - 06/2004
6	Hypoxia (Hypoxemia) 01/2020 - 04/2005
4	COVID-19 01/2022 - 09/2020
4	Hemorrhagic Shock 05/2015 - 05/2007
3	Ischemia 01/2022 - 05/2007
3	Infections 09/2020 - 06/2004
3	Pneumonia (Pneumonitis) 12/2019 - 06/2008
3	Lung Injury 01/2019 - 05/2015
3	Sepsis (Septicemia) 04/2016 - 02/2005
2	Weight Loss (Weight Reduction) 01/2021 - 01/2020
2	Brain Injuries (Brain Injury) 01/2021 - 12/2018
2	Short Bowel Syndrome 01/2020 - 01/2018
2	Dehydration (Water Stress) 12/2019 - 01/2018
2	Bacterial Infections (Bacterial Infection) 12/2019 - 12/2008
2	Endotoxemia 06/2015 - 05/2015
2	Hemorrhage 10/2014 - 05/2007
1	Anemia 01/2022
1	Neuroinflammatory Diseases 01/2021
1	Ulcerative Colitis 10/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2020
1	Virus Diseases (Viral Diseases) 09/2020
1	Dysbiosis 01/2020
1	Malnutrition (Nutritional Deficiencies) 12/2019
1	Intestinal Failure 12/2019
1	Neoplasms (Cancer) 01/2019
1	MYD88 Deficiency 01/2019
1	Cognitive Dysfunction 12/2018
1	Lung Diseases (Lung Disease) 01/2018
1	Arterial Occlusive Diseases (Arterial Occlusive Disease) 01/2018
1	Bone Diseases (Bone Disease) 08/2017
1	Alcoholism (Alcohol Abuse) 01/2017
1	Body Weight (Weight, Body) 01/2017
1	Enterocolitis 10/2016
1	Colitis 05/2016
1	Gram-Negative Bacterial Infections 04/2016

Drug/Important Bio-Agent (IBA)

17	Toll-Like Receptor 4IBA 01/2021 - 06/2007
15	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2022 - 03/2008
9	EndotoxinsIBA 10/2020 - 06/2004
8	LipopolysaccharidesIBA 10/2020 - 06/2004
7	HMGB1 Protein (HMG1)IBA 12/2015 - 05/2007
6	Proteins (Proteins, Gene)FDA Link 11/2021 - 10/2012
5	Angiotensin-Converting Enzyme 2IBA 01/2022 - 01/2018
5	LigandsIBA 01/2019 - 05/2007
4	OligosaccharidesIBA 01/2021 - 10/2016
3	2'-fucosyllactoseIBA 01/2021 - 10/2016
3	CarbohydratesIBA 01/2020 - 01/2016
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2007 - 09/2004
2	Messenger RNA (mRNA)IBA 01/2021 - 01/2017
2	6'-sialyllactoseIBA 01/2021 - 01/2021
2	EnzymesIBA 01/2020 - 10/2019
2	Interleukin-17 (Interleukin 17)IBA 12/2019 - 05/2015
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2019 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 05/2007
2	Interleukin-6 (Interleukin 6)IBA 05/2015 - 10/2014
2	Interferon-gamma (Interferon, gamma)IBA 09/2008 - 06/2007
2	GTP Phosphohydrolases (GTPases)IBA 11/2007 - 02/2005
2	SodiumIBA 02/2005 - 08/2004
2	Protons (Proton)IBA 02/2005 - 08/2004
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2021
1	SugarsIBA 01/2021
1	Lactose FDA LinkGeneric 01/2021
1	Dextran SulfateIBA 10/2020
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 09/2020
1	Lipocalin-2IBA 01/2020
1	MicronutrientsIBA 12/2019
1	Interleukin-23 (Interleukin 23)IBA 10/2019
1	Interleukin-22 (IL-22)IBA 10/2019
1	LipidsIBA 10/2019
1	CC ChemokinesIBA 01/2019
1	Surface-Active Agents (Surfactants)IBA 01/2019
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2019
1	ElectrolytesIBA 01/2018
1	Bradykinin Receptors (Bradykinin Receptor)IBA 01/2018
1	Angiotensin IIIBA 01/2018
1	Oxyhemoglobins (Oxyhemoglobin)IBA 01/2018
1	Peptides (Polypeptides)IBA 01/2018
1	BradykininIBA 01/2018
1	Biological ProductsIBA 01/2018
1	ChemokinesIBA 01/2018
1	CarboxypeptidasesIBA 01/2018
1	Naloxone (Narcan)FDA LinkGeneric 01/2017
1	Ethanol (Ethyl Alcohol)IBA 01/2017
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 05/2016
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2016
1	Dextrans (Dextran)FDA Link 05/2016
1	Interleukin-10 (Interleukin 10)IBA 04/2016
1	Dopamine (Intropin)FDA LinkGeneric 02/2016
1	ProstaglandinsIBA 02/2016
1	Dinoprostone (PGE2)FDA Link 02/2016
1	gamma-Aminobutyric Acid (GABA)IBA 02/2016

Therapy/Procedure

4	Therapeutics 12/2018 - 04/2006
2	Intraperitoneal Injections 01/2021 - 06/2007
2	Resuscitation 10/2014 - 05/2007
2	Laparotomy 05/2006 - 04/2006
1	Blood Transfusion (Blood Transfusions) 01/2022
1	Critical Care (Surgical Intensive Care) 09/2020
1	Ostomy 01/2018
1	Ligation 01/2018